GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9457247 | 1 | rs422562 | chr6:167406318 | RNASET2 | chr6:167343008-167412795:- | -0.46 | -7.5 | 3.29E-11 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs422694 | chr6:167406074 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs9457247 | 1 | rs422780 | chr6:167406209 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs4237643 | 1 | rs4237643 | chr11:43648368 | HSD17B12 | chr11:43702143-43878160:+ | 0.57 | 5.83 | 7.53E-8 | Forced vital capacity |
| THYM | cis | rs9902453 | 1 | rs4239227 | chr17:28389103 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs42648 | 1 | rs42648 | chr7:89977760 | GTPBP10 | chr7:89969690-90016650:+ | 0.29 | 4.76 | 7.02E-6 | Homocysteine levels |
| THYM | cis | rs42648 | 1 | rs42649 | chr7:89977789 | GTPBP10 | chr7:89969690-90016650:+ | 0.29 | 5.03 | 2.31E-6 | Homocysteine levels |
| THYM | cis | rs42648 | 1 | rs42656 | chr7:89981636 | GTPBP10 | chr7:89969690-90016650:+ | 0.29 | 4.76 | 7.02E-6 | Homocysteine levels |
| THYM | cis | rs42648 | 1 | rs42658 | chr7:89981915 | GTPBP10 | chr7:89969690-90016650:+ | 0.26 | 4.39 | 2.95E-5 | Homocysteine levels |
| THYM | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | CENPQ | chr6:49431096-49460820:+ | 0.24 | 4.17 | 6.68E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | MUT | chr6:49398994-49431031:- | -0.29 | -4.38 | 3.0E-5 | Folate pathway vitamin levels |
| THYM | cis | rs2243480 | 1 | rs427044 | chr7:65508545 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs2273 | 1 | rs4282209 | chr4:76919536 | NAAA | chr4:76831809-76862166:- | -0.45 | -4.79 | 6.23E-6 | Longevity |
| THYM | cis | rs9457247 | 1 | rs429083 | chr6:167383972 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs4294134 | 1 | rs4294134 | chr7:135293128 | PL-5283 | chr7:135347221-135378160:+ | 0.35 | 4.87 | 4.51E-6 | Paget's disease |